No.3982
Anime, maybe clannad, the train scene was the only thing that genuinely got me and Grave of the Fireflies, after my first watch, when I watched it again sometime later, when the train guard throws away the sweet tin and Setsuko comes out, that had me in tears.
As for manga, YKK, though it's not tears of sadness, the manga at some points just hits me with such intense feelings of nostalgia and other emotions that I end up tearing up even if it's not sad.